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TCPTP 10ug

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货号：14-646

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-646
Brand Family Upstate
Trade Name
  • Upstate
Description TCPTP Protein, 10 µg
Overview Un-tagged, recombinant, human TCPTP, amino acids 1-341.
References
Product Information
Applications
Application Un-tagged, recombinant, human TCPTP, amino acids 1-341. For use in Phosphatase Assays.
Key Applications
  • Phosphatase Assay
Biological Information
Source Human TCPTP, expressed in E. coli cells.
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.
Gene Symbol
  • PTPN2
  • TCELLPTP
  • TCPTP
  • TC-PTP
  • PTPT
Protein Target TCPTP
Purification Method Glutathione agarose affinity chromatography
Target Sub-Family Tyr phosphatase
UniProt Number
UniProt Summary SIZE: 415 amino acids; 48528 Da
SUBUNIT: Interacts with FAM82C/PTPIP51.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: PTPA isoform is probably the major PTP expressed in human tissues. PTPB isoform was found in T-cells and in placenta.
SIMILARITY: SwissProt: P17706 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. & Contains 1 tyrosine-protein phosphatase domain.
Molecular Weight 39.7kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by dephosphorylation of DiFMUP.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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