[关闭]
您好！欢迎来到炼石商城   请登录  注册    兼职小伙伴  
我的购物车
0
Qiagen 凯杰 Biosharp Omega

首页抗体Millipore 密理博>

图片仅供参考，请以实物为准
收藏

Anti-C4d (rabbit polyclonal)

市场价：
0.00
促销价：
¥0.00

货号：ABF11

品牌：Millipore 密理博

配送至：

支付： 账期 货到付款

数量：

EA (预计3-5工作日到货)

亲，想了解价格请QQ咨询客服！

工作时间

周一至周五：9:00-18:00

咨询电话

0771-3293894

在线咨询

客服 郭恒 蔡玉坤 曾宪飞 技术咨询

浏览了该商品的用户最终购买

RNeasy Mini Kit (50) 50次
RNeasy Mini Kit (50) 50次
3720.00
Plasmid Mini Kit I(200) 200次
Plasmid Mini Kit I(200) 200...
576.00
10ul吸头，透明，袋装，可灭菌 1000支/袋，50袋/箱
10ul吸头，透明，袋装，可灭菌...
85.80

浏览了该商品的用户还浏览了

QIAfilter Plasmid Maxi Kit (10) -10
QIAfilter Plasmid Maxi Kit (...
3000.00
QIAamp DNA Blood Midi Kit (20) 20次
QIAamp DNA Blood Midi Kit (2...
2680.00
QIAamp UCP Pathogen Mini Kit (50)
QIAamp UCP Pathogen Mini Kit...
4112.00
Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M WB Rb Purified Polyclonal Antibody
Description
Catalogue Number ABF11
Description Anti-C4d Antibody
Alternate Names
  • complement component 4B (Chido blood group)
  • basic C4
  • complement C4B1a
  • complement component 4B
  • Basic complement C4
  • Chido form of C4
  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
Background Information C4d is a degradation product of activated Complement 4 (C4), a central component in the classical complement cascade pathway. This pathway is typically activated by specific antibody binding to select target molecules, making C4d an indirect footprint or marker of antibody response. After cleavage occurs, C4d is left with several exposed ester groups that allow for C4d to bind in a transient, covalent manner to endothelial cell surfaces along with components of ECM vascular basement membranes near C4 activation sites. Due to the strength of these bonds and Cd4’s ability to act as an indirect marker of antibody response, this degradation product has become a significant marker, both general and robust, for humoral rejection of transplants including allografts from cardiac, kidney, and liver tissues. It has also been shown to bind platelets associating Cd4 as a marker for both stroke severity and ischemic stroke (Mehta, et al., 2008).
References
Product Information
Format Purified
Control
  • Aged mouse serum
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-C4d Antibody is validated for use in WB for the detection of C4d.
Key Applications
  • Western Blotting
Biological Information
Immunogen Linear peptide corresponding to mouse C4d.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes the region corresponding to C4d in the complement C4/C4b complex and its subsequent cleavage products during C4 maturation. C4b is the first cleavage product of C4, but it is difficult to visualize rapid conversion to C4d by factor I.
Isotype IgG
Species Reactivity
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • CPAMD3
  • C4B5
  • CO4
  • C4F
  • C4B2
  • C4B1
  • CH
  • C4B12
  • C4B3
  • C4b
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway.

SUBUNIT STRUCTURE: Circulates in blood as a disulfide-linked trimer of an alpha, beta and gamma chain.

SUBCELLULAR LOCATION: Secreted.

PTM: Prior to secretion, the single-chain precursor is enzymatically cleaved to yield the non-identical chains (alpha, beta and gamma). During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.

MISCELLANEOUS: C4 is a major histocompatibility complex class-III protein.

SEQUENCE SIMILARITIES: Contains 1 anaphylatoxin-like domain.

Contains 1 NTR domain.
Molecular Weight ~41 kDa observed, corresponding to the C4d cleavage product in aged mouse serum.
Western Blot of mouse serum aged for different intervals revealed a band at ~200 kDa (day 0) corresponding to the molecular weight of the complement C4/C4b complex and a band at ~41 kDa (day 1) corresponding to the molecular weight of cleavage product C4d, after rapid conversion of the cleavage product C4b (Murata, K., et al., 2007).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in mouse serum aged for 0 and 1 day.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected C4d as a singular cleavage product, as well as within the C4/C4b complex in 10 µg of aged mouse serum.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

温馨提示:因厂家更改产品包装、产地或者更换随机附件等没有任何提前通知，且每位咨询者购买情况、提问时间等不同，为此以下回复仅对提问者3天内有效，其他网友仅供参考！若由此给您带来不便请多多谅解，谢谢！

我要咨询

咨询内容：
购物指南 免费注册 批量采购 购物流程 购物保障
配送方式 上门自提 第三方配送 炼石配送
支付方式 货到付款 账期付款
售后服务 售后政策 退款说明 售后流程 免责条款

服务热线

0771-3293894

关于我们|帮助中心|诚聘英才|炼石云实验室|联系我们|友情链接

Copyright 2014-2025 炼石云商网络科技（海南）有限公司版权所有 琼ICP备2023006525号-3