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Anti-Cytochrome P450 1B1 (rabbit polyclonal)

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货号：AB10320

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB Rb Serum Polyclonal Antibody
Description
Catalogue Number AB10320
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Cytochrome P450 1B1 Antibody
Alternate Names
  • Cytochrome P450 1B1
Background Information Cytochrome P450 1B1 (CYP1B1) is active in the metabolism of estrogens to reactive catechols and of different procarcinogens. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids.
References
Product Information
Format Serum
Presentation Raw rabbit serum with 0.05% sodium azide.
Applications
Application Anti-1B1 Antibody detects level of 1B1 & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Suggested dilutions:
Western Blot: 1:5000
Biological Information
Immunogen Recombinant human 1B1
Host Rabbit
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
Gene Symbol
  • CP1B
  • CYPIB1
  • EC 1.14.14.1
  • GLC3A
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q16678 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
SIZE: 543 amino acids; 60846 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
SIMILARITY: SwissProt:Q16678 # Belongs to the cytochrome P450 family.
Molecular Weight 61kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C for up to 12 months from date of receipt.
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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