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Anti-Cdk5, clone 1H3 (mouse monoclonal)

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货号：MABS50

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, ICC, IHC M Purified Monoclonal Antibody
Description
Catalogue Number MABS50
Description Anti-Cdk5 Antibody, clone 1H3
Alternate Names
  • cyclin-dependent kinase 5
  • Tau protein kinase II catalytic subunit
  • Serine/threonine-protein kinase PSSALRE
  • protein kinase CDK5 splicing
  • TPKII catalytic subunit
Background Information Cyclin-dependent kinase 5 (CDK5), belongs to the cyclin-dependent kinase family. It is most active in the central nervous system and plays an important role in the regulation of cytoskeletal function. CDK5 expression has been observed in testis, kidney, and ovary with higher levels seen in postmitotic neurons in developing and adult nervous systems. Mutations in CDK5 have been associated with Alzheimer's disease, Parkinson's disease, and ALS, suggesting that CDK5 may play a key role in several neurodegenerative disorders.
References
Product Information
Format Purified
Control
  • HeLa cell lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Cdk5 Antibody, clone 1H3 detects level of Cdk5 & has been published & validated for use in WB, IC, IH.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes Immunocytochemistry Analysis: This antibody has been shown to detect CDK5 in mouse brain histological sections. (Legace, D.C., et al. (2008). Proc Natl Acad Sci USA. 105:18567-18571.)
Biological Information
Immunogen Human CDK5 cross linked to homogenized surgical suture material
Clone 1H3
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes CDK5.
Isotype IgG1κ
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CDK5
  • PSSALRE
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.

SIZE: 292 amino acids; 33304 Da

SUBUNIT: Heterodimer of a catalytic subunit and a regulatory subunit (p35). Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 (By similarity). Interacts with AATK.

SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, growth cone (By similarity). Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity).

SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain. ... hide » see more »
Molecular Weight 33 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected CDK5 on 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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