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Anti-MKP1

市场价：: 0.00

促销价：: ¥0.00

货号：07-535

品牌：Millipore 密理博

配送至：

北京朝阳

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数量：

EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB	Rb	Purified	Polyclonal Antibody

Description
Catalogue Number	07-535
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-MKP1 Antibody

References

Product Information
Format	Purified
Control	Positive Control Included: 3T3 Cell Lysate (12-305)
Presentation	Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.

Applications
Application	Detect MKP1 using this Anti-MKP1 Antibody validated for use in WB.
Key Applications	Western Blotting

Biological Information
Immunogen	peptide corresponding to amino acids 87-101 (DERSAALDGAKRDGT-C) of human MAP kinase phosphatase 1 (MKP1)
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Recognizes MKP1.
Isotype	IgG
Species Reactivity	Human Mouse
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_004417
Entrez Gene Summary	The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Gene Symbol	DUSP1 VH1 YVH1 HVH1 MKP1 MKP-1 PTPN10 CL100
Purification Method	Protein A Purfied
UniProt Number	P28562
UniProt Summary	FUNCTION: SwissProt: P28562 # Dual specificity phosphatase that dephosphorylates MAP kinase ERK2 on both 'Thr-183' and 'Tyr-185'. SIZE: 367 amino acids; 39298 Da TISSUE SPECIFICITY: Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. SIMILARITY: SwissProt: P28562 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. & Contains 1 rhodanese domain. & Contains 1 tyrosine-protein phosphatase domain.
Molecular Weight	42 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	routinely evaluated by immunoblot in RIPA lysates from 3T3/A31 cells
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

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