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Anti-Stargazin/Cacng2, CT

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货号：07-577

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R, M ICC, IP, WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 07-577
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Stargazin/Cacng2 Antibody, CT
Alternate Names
  • Neuronal voltage-gated calcium channel gamma-2 subunit
  • calcium channel, voltage-dependent, gamma subunit 2
  • voltage-dependent calcium channel gamma-2 subunit
Background Information Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state.
There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival.
References
Product Information
Format Purified
Control
  • Brain tissue
Presentation Purified rabbit polyclonal IgG in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide before the addition of glycerol to 30%.
Applications
Application This Anti-Stargazin/Cacng2 Antibody, CT is validated for use in IC, IP, WB for the detection of Stargazin/Cacng2.
Key Applications
  • Immunocytochemistry
  • Immunoprecipitation
  • Western Blotting
Application Notes Immunoprecipitation:
2-5 µg of this antibody has been reported by an independent laboratory to immunoprecipitate Stargazin in rat P2 lysate.
Biological Information
Immunogen KLH-conjugated, synthetic peptide corresponding to amino acids 305-323 (KDSKDSLHANTANRRTTPV) of rat Stargazin.
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes Stargazin, MW ~36-39 kDa.
Isotype IgG
Species Reactivity
  • Rat
  • Mouse
Species Reactivity Note Rat. Predicted to cross-react with mouse based on sequence similarity.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which have been associated with absence seizures, also known as petit-mal or spike-wave seizures. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family.
Gene Symbol
  • CACNG2
  • MGC138502
  • MGC138504
  • stargazin
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9Y698 # Thought to stabilize the calcium channel in an inactivated (closed) state.
SIZE: 323 amino acids; 35966 Da
SUBUNIT: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Brain.
PTM: Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4.
SIMILARITY: SwissProt: Q9Y698 ## Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
Molecular Weight ~36-39 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by western blot on RIPA lysates from rat brain microsomal preparation (Catalog # 12-144).

Western Blot Analysis:
0.5-2.0 µg/mL of this antibody detected Stargazin in RIPA lysates from rat brain microsomal preparation (Catalog # 12-144).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20ºC from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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