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Anti-Integrin ?1 (human), clone 5E8D9 (mouse monoclonal)

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货号：05-246

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ICC, NEUT M Purified Monoclonal Antibody
Description
Catalogue Number 05-246
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Integrin α1 Antibody, clone 5E8D9
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl
Applications
Application Anti-Integrin α1 Antibody, clone 5E8D9 is an antibody against Integrin α1 for use in IC, NEUT.
Key Applications
  • Immunocytochemistry
  • Neutralizing
Biological Information
Immunogen Purified human integrinα1
Clone 5E8D9
Host Mouse
Specificity integrinα1
Isotype IgG2a
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.
Gene Symbol
  • ITGA1
  • CD49a
  • VLA1
  • VLA-1
Purification Method Protein A chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: P56199 # Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen.
SIZE: 1179 amino acids; 130848 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: SwissProt: P56199 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
Molecular Weight 150kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated on cold ethanol fixed cells in immunocytochemistry
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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