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Anti-Cyclin E, clone HE12, human (mouse monoclonal IgG)

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货号：05-363

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H IP, WB, ICC M Purified Monoclonal Antibody
Description
Catalogue Number 05-363
Replaces 04-223
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Cyclin E Antibody, clone HE12
Background Information Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
References
Product Information
Format Purified
Control
  • A431 cell lysate
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide
Applications
Application Anti-Cyclin E Antibody, clone HE12 is a high quality Mouse Monoclonal Antibody for the detection of Cyclin E & has been validated in IP, WB, ICC.
Key Applications
  • Immunoprecipitation
  • Western Blotting
  • Immunocytochemistry
Biological Information
Immunogen Recombinant human cyclin E
Clone clone HE12
Host Mouse
Specificity human p52cyclin E
Isotype IgG
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
Gene Symbol
  • CCNE1
  • CCNE
Purification Method Protein G Chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: P24864 # Essential for the control of the cell cycle at the G1/S (start) transition.
SIZE: 410 amino acids; 47077 Da
SUBUNIT: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
PTM: Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: P24864 ## Belongs to the cyclin family. Cyclin E subfamily.
Molecular Weight 52 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated in immunoblot on human A431 lysate
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C or 6 months at 4°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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