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PKC Theta, active BULK SIZE 250ug

市场价：
32.00
促销价：
¥0.00

货号：14-444M

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-444M
Brand Family Upstate
Trade Name
  • Upstate
Description PKC θ Protein, active, 250 µg
Overview Recombinant full-length human PKC theta with a C-terminal 6His-tag

PKC Lipid activator (Catalog # 20-133) is required for use.
References
Product Information
Applications
Application Active, recombinant full-length human PKC theta with a C-terminal 6His-tag. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source expressed in Sf21 cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
Gene Symbol
  • PRKCQ
  • OTTHUMP00000043365
  • MGC126514
  • OTTHUMP00000043364
  • MGC141919
  • PRKCT
  • nPKC-theta
Protein Target PKCθ
Purification Method immobilized nickel affinity chromatography
Target Sub-Family AGC
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q04759 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
COFACTOR: Magnesium.
SIZE: 706 amino acids; 81865 Da
SUBUNIT: Interacts with TXNL2/PICOT.
TISSUE SPECIFICITY: Skeletal muscle, megakaryoblastic cells and platelets.
DOMAIN: SwissProt: Q04759 The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
PTM: Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation.
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
Molecular Weight 83kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of Histone H1 substrate in vitro
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70 °C
Packaging Information
Material Size 250 µg
Material Package Also available in 10 μg size (cat#14-444) and in bulk (cat# 14-444-K).
Transport Information
Supplemental Information
Specifications

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