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p70 S6 Kinase (T412E),active 250ug

市场价：
32.00
促销价：
¥0.00

货号：14-486M

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-486M
Brand Family Upstate
Trade Name
  • Upstate
Description p70 S6 Kinase Protein, active, 250 µg
Overview N-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase
References
Product Information
Applications
Application Active, N-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source Expressed in Sf21 cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
Gene Symbol
  • RPS6KB1
  • p70-alpha
  • p70S6k
  • p70-S6K
  • p70
  • S6K
  • S6Kalpha)
  • P70S6K
  • STK14A
  • S6K1
  • p70(S6K)-alpha
  • PS6K
Protein Target p70S6K
Purification Method Ni2+/NTA-agarose
Target Sub-Family AGC
UniProt Number
UniProt Summary FUNCTION: SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.
SIZE: 525 amino acids; 59140 Da
SUBUNIT: Interacts with PPP1R9A/neurabin-1 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity).
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
Molecular Weight 48.7kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by phosphorylation of S6 Kinase/Rsk-2 Substrate Peptide 2
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C
Packaging Information
Material Size 250 µg
Material Package Also available in 10 μg size (cat#14-486) and in bulk (cat# 14-486-K).
Transport Information
Supplemental Information
Specifications

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