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PAK3, active 10ug

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货号：14-683

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-683
Brand Family Upstate
Trade Name
  • Upstate
Description PAK3 Protein, active, 10 µg
Overview C-terminal 6His-tagged, recombinant, human full length, PAK3.

mitosis
References
Product Information
Applications
Application Active, C-terminal 6His-tagged, recombinant, human full length, PAK3. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source PAK3 expressed by baculovirus in Sf21 cells.
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.
Gene Symbol
  • PAK3
  • oligophrenin-3
  • CDKN1A
  • OPHN3
  • PAK3beta
  • PAK-3
  • Beta-PAK
  • OTTHUMP00000062894
  • Oligophrenin-3
  • hPAK3
  • MRX47
  • MRX30
  • bPAK
Protein Target PAK3
Purification Method Ni2+/NTA-agarose
Target Sub-Family STE
UniProt Number
UniProt Summary FUNCTION: SwissProt: O75914 # Key regulator of synapse formation and plasticity in the hippocampus (By similarity).
COFACTOR: Magnesium (By similarity).
SIZE: 559 amino acids; 62310 Da
SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK.
TISSUE SPECIFICITY: Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
PTM: Autophosphorylated when activated by CDC42/p21.
DISEASE: SwissProt: O75914 # Defects in PAK3 are the cause of non-syndromic mental retardation X-linked type 30 (MRX30) [MIM:300558]; also called X- linked mental retardation type 47 (MRX47). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs.
SIMILARITY: SwissProt: O75914 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
Molecular Weight 63.2kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of PAKtide (RRRLSFAEPG).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C from date of shipment
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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