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IRAK1, active 10ug

市场价：: 0.00

促销价：: ¥0.00

货号：14-684

品牌：Millipore 密理博

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北京朝阳

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Replacement Information

Description
Catalogue Number	14-684
Brand Family	Upstate
Trade Name	Upstate
Description	IRAK1 Protein, active, 10 µg
Overview	N-terminal 6His-tagged, recombinant, human IRAK1 amino acids 194-end.

References

Product Information

Applications
Application	Active, N-terminal 6His-tagged, recombinant, human IRAK1 amino acids 194-end. For use in Kinase Assays.
Key Applications	Kinase Assay

Biological Information
Source	Human IRAK1 expressed by baculovirus in Sf21 cells.
Specific Activity	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number	NM_001025242.1 NM_001025243.1 NM_001569.3
Entrez Gene Summary	This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Symbol	IRAK1 IRAK IRAK-1 pelle
Protein Target	IRAK1
Purification Method	Ni²⁺/NTA-agarose
Target Sub-Family	TKL
UniProt Number	P51617
UniProt Summary	FUNCTION: SwissProt: P51617 # Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1. COFACTOR: Magnesium. SIZE: 712 amino acids; 76537 Da SUBUNIT: IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1. TISSUE SPECIFICITY: Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. PTM: Autophosphorylated or is transphosphorylated by IRAK4 following recruitment to the IL-1RI. In the case of isoform 1, this is linked to ubiquitination and degradation. SIMILARITY: SwissProt: P51617 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 protein kinase domain.
Molecular Weight	59.7kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	routinely evaluated by phosphorylation of MBP (13-104).
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	6 months at -70°C from date of shipment

Packaging Information
Material Size	10 µg
Material Package	Also available in 250 µg size --call for pricing and availability and reference catalog number 14-684M when ordering the 250 µg size.

Transport Information

Supplemental Information

Specifications

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