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MST3, active 10ug

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货号：14-695

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-695
Brand Family Upstate
Trade Name
  • Upstate
Description MST3 Protein, active, 10 µg
Overview N-terminal GST-tagged, recombinant, human MST3, amino acids 1-304
References
Product Information
Applications
Application Active, N-terminal GST-tagged, recombinant, human MST3, amino acids 1-304, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source expressed by baculovirus in Sf21 cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 [PubMed 10644707]).[supplied by OMIM]
Gene Symbol
  • STK24
  • MST3B
  • MST3
  • MST-3
  • STK3
Protein Target MST3
Purification Method Glutathione agarose affinity chromatography
Target Sub-Family STE
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9Y6E0 # Protein kinase that act on both serine and threonine residues.
COFACTOR: Manganese. Only isoform A requires manganese.
SIZE: 443 amino acids; 49308 Da
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
PTM: Autophosphorylated. Isoform B is activated by phosphorylation by PKA.
SIMILARITY: SwissProt: Q9Y6E0 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 protein kinase domain.
Molecular Weight 61.2kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of PKCtide (Catalog# 12-536)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions stable for 6 months at -70°C from date of shipment
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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