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PAK5, active 10ug

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货号：14-699

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-699
Brand Family Upstate
Trade Name
  • Upstate
Description PAK5 Protein, active, 10 µg
Overview N-terminal 6His-tagged, recombinant, human PAK5, amino acids 425-end. PAK5 is also known as PAK7.
References
Product Information
Applications
Application Active, N-terminal 6His-tagged, recombinant, human PAK5, amino acids 425-end. PAK5 is also known as PAK7. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source expressed by baculovirus in Sf21 cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.
Gene Symbol
  • PAK7
  • PAK-5
  • PAK5
  • MGC26232
  • KIAA1264
  • PAK-7
Protein Target PAK5
Purification Method Ni2+/NTA-agarose
Target Sub-Family STE
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9P286 # The activated kinase acts on a variety of targets (By similarity).
SIZE: 719 amino acids; 80745 Da
SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity).
TISSUE SPECIFICITY: Predominantly expressed in brain.
PTM: Autophosphorylated when activated by CDC42/p21 (By similarity).
SIMILARITY: SwissProt: Q9P286 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
Molecular Weight 37.4kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of PAKtide
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C from date of shipment
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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