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CaM Kinase IId, active 10ug

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货号：14-723

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-723
Brand Family Upstate
Trade Name
  • Upstate
Description CaM Kinase IIδ Protein, active, 10 µg
Overview N-terminal 6His-tagged, recombinant, human, full length CaM Kinase IIδ

N-terminal 6His-tagged, recombinant, human, full length CaM Kinase IIδ
References
Product Information
Applications
Application Active, N-terminal 6His-tagged, recombinant, human, full length CaM Kinase IIδ. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source expressed by baculovirus in Sf21 cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Four alternatively spliced transcript variants that encode three different isoforms have been characterized to date. Distinct isoforms of this chain have different expression patterns.
Gene Symbol
  • CAMK2D
  • CAMKD
  • MGC44911
Protein Target CaMKIIδ
Purification Method Ni2+/NTA-agarose
Target Sub-Family CAMK
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q13557 # CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.
SIZE: 499 amino acids; 56369 Da
SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.
TISSUE SPECIFICITY: Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle.
SIMILARITY: SwissProt: Q13557 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
MISCELLANEOUS: Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy.
Molecular Weight 58kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of 250μM ZIPtide (Catalog # 12-545)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C from date of shipment
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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