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Anti-PI3 Kinase p85, agarose conjugate

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货号：16-107

品牌：Millipore 密理博

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Description
Catalogue Number 16-107
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-PI3 Kinase Antibody, p85 Protein, agarose conjugate, 200 µg
Overview Anti-PI 3-Kinase antibody (06-195) covalently coupled to protein A-agarose by dimethyl-pimelimidate.
References
Product Information
Format Gel Immobilized
Presentation PBS, pH 7.4, containing 0.05% sodium azide
Applications
Application Anti-PI3 Kinase Antibody, p85, agarose conjugate detects level of PI3 Kinase & has been published & validated for use in IP.
Key Applications
  • Immunoprecipitation
Application Notes Suitable for immunoprecipitation and affinity purification.
Biological Information
Host Rabbit
Species Reactivity
  • Rat
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
Gene Symbol
  • PIK3R1
  • GRB1
  • PI3K
  • p85-ALPHA
Target Sub-Family PI3K/PI4K
UniProt Number
UniProt Summary FUNCTION: SwissProt: P27986 # Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
SIZE: 724 amino acids; 83598 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits. Interacts with phosphorylated TOM1L1. Interacts with phosphorylated LIME1 upon TCR and/or BCR activation. Interacts with SOCS7. Interacts with RUFY3 (By similarity). Interacts with phosphorylated LAT, LAX1 and TRAT1 upon TCR activation. Interacts with CBLB. Interacts with HIV-1 Nef to activate the Nef associated p21-activated kinase (PAK). This interaction depends on the C- terminus of both proteins and leads to increased production of HIV. Interacts with HCV NS5A. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with IRS1.
TISSUE SPECIFICITY: Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
DOMAIN: SwissProt: P27986 The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.
PTM: Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.DISEASE:SwissProt: P27986 # Defects in PIK3R1 are a cause of severe insulin resistance.
SIMILARITY: Belongs to the PI3K p85 subunit family. & Contains 1 Rho-GAP domain. & Contains 2 SH2 domains. & Contains 1 SH3 domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoprecipitating PI 3-Kinase from RIPA lysate of EGF-stimulated human A431 carcinoma cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 1 year at 4°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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