Anti-MLLN /HRX, clone N4.4 (mouse monoclonal IgG1 ) - 炼石商城

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Anti-MLLN /HRX, clone N4.4 (mouse monoclonal IgG1 )

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货号：05-764

品牌：Millipore 密理博

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	IP, WB	M	Purified	Monoclonal Antibody

Description
Catalogue Number	05-764
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-MLL/HRX Antibody, NT., clone N4.4
Background Information	The acute lymphoblastic leukaemia (ALL)-1 (also known as MLL, HRX, HTRX, and TRX1) gene on human chromosome 11q23 is the site of many locally clustered chromosomal alterations associated with several types of acute leukaemias, including deletions, partial duplications and translocations. Structurally variant proteins derived from the altered gene presumably cause the malignant transformation of early haemopoietic progenitor cells.

References

Product Information
Format	Purified
Control	K562 nuclear extract
Presentation	Immunoaffinity Purified immunoglobulin in 0.014M phosphate buffer, pH 7.6, 0.175M NaCl, 0.07% sodium azide, and 30% glycerol.

Applications
Application	Detect MLL/HRX with Anti-MLL/HRX Antibody, N-term., clone N4.4 (Mouse Monoclonal Antibody), that has been shown to work in IP & WB.
Key Applications	Immunoprecipitation Western Blotting

Biological Information
Immunogen	MBP fusion protein corresponding to residues 161-356 of human mixed lineage leukemia, MLL
Clone	N4.4
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	Recognizes N-terminal proteolytic fragment of MLL (MLLN).
Isotype	IgG1
Species Reactivity	Human Mouse
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_005933
Gene Symbol	MLL HRX CXXC7 ALL1 HTRX1 TRX1 FLJ11783 ALL-1 MLL/GAS7 HTRX MLL1A
Purification Method	Protein G Purified
UniProt Number	Q03164
UniProt Summary	FUNCTION: SwissProt: Q03164 # Possibly acts as a transcriptional regulatory factor. SIZE: 3969 amino acids; 431764 Da SUBUNIT: Interacts with SBF1. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Heart, lung, brain and T- and B-lymphocytes. DISEASE: SwissProt: Q03164 # Chromosomal aberrations involving MLL are a cause of acute leukemias. Translocation t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation t(3,11)(q25,q23) with GMPS; translocation t(4;11)(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23) with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5-alpha/CENPK; translocation t(6;11)(q27;q23) with MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11.2;q23) with ABI1; translocation t(10;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13.3) with ELL; translocation t(11;19)(q23;p13.3) with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1. Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with CXXC6. Translocation t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. & A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with SEPT11. SIMILARITY: SwissProt: Q03164 ## Belongs to the TRX/MLL family. & Contains 3 A.T hook DNA-binding domains. & Contains 1 bromo domain. & Contains 1 CXXC-type zinc finger. & Contains 3 PHD-type zinc fingers. & Contains 1 post-SET domain. & Contains 1 SET domain.
Molecular Weight	300 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	routinely evaluated by immunoblot on nuclear extract from K562 cells
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Packaging Information
Material Size	200 µg

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