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Ms X ABCA1 Monoclonal Antibody

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货号：MAB10005

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Ch, H, M ELISA, IP, WB, IH(P) M Purified Monoclonal Antibody
Description
Catalogue Number MAB10005
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-ABCA1 Antibody, clone AB.H10
Alternate Names
  • ATP-binding cassette transporter 1
  • ABC-1
  • Cholesterol efflux regulatory protein
Background Information Mutations in the ABCA1 gene are associated with Tangier disease (TD). TD is an autosomal recessive disorder results from an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and disorders in cellular lipid trafficking. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
References
Product Information
Format Purified
Presentation Presented as a liquid in PBS, pH 7.4 with 0.05% sodium azide.
Applications
Application This Anti-ABCA1 Antibody, clone AB.H10 is validated for use in ELISA, IP, WB, IH(P) for the detection of ABCA1.
Key Applications
  • ELISA
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes ELISA
Immunohistochemistry (Paraffin): 5 μg/mL. Perform heat mediated antigen retrieval in sodium citrate buffer (pH 6), before commencing with IHC staining protocol. Amplification with biotin-streptavidin may be required.
Immunoprecipitation
Western Blot: 1 μg/mL. Predicted molecular weight: 254 kDa.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Recombinant fragment, corresponding to amino acids 1800-2260 of Human ABCA1.
Clone AB.H10
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Recognize specifically ABCA1 from human, mouse, and chicken.
Isotype IgG1
Species Reactivity
  • Chicken
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
Gene Symbol
  • ABCA1
  • MGC165011
  • HDLDT1
  • ABC1
  • TGD
  • CERP
  • membrane-bound
  • TD
  • ABC-1
  • MGC164864
  • FLJ14958
UniProt Number
UniProt Summary FUNCTION: SwissProt: O95477 # cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
SIZE: 2261 amino acids; 254286 Da
SUBUNIT: Interacts with MEGF10.
TISSUE SPECIFICITY: Widely expressed, but most abundant in macrophages.
DOMAIN: SwissProt: O95477 Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
PTM: Phosphorylation on Ser-2054 regulates phospholipid efflux.
DISEASE: SwissProt: O95477 # Defects in ABCA1 are a cause of high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness. & Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.
SIMILARITY: Belongs to the ABC transporter family. ABCA subfamily. & Contains 2 ABC transporter domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will be stable at 4°C for 3 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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