[关闭]
您好!欢迎来到炼石商城   请登录  注册    兼职小伙伴  
我的购物车
0
Qiagen 凯杰 Biosharp Omega

首页抗体Millipore 密理博>

图片仅供参考,请以实物为准
收藏

Anti-Vav

价:
0.00
价:
¥0.00

号:07-192

牌:Millipore 密理博

账期 货到付款

EA (预计3-5工作日到货)

亲,想了解价格请QQ咨询客服!

工作时间

周一至周五:9:00-18:00

咨询电话

0771-3293894

在线咨询

客服 郭恒 蔡玉坤 曾宪飞 技术咨询

浏览了该商品的用户还浏览了

Replacement Information

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, IHC Rb Unpurified Polyclonal Antibody
Description
Catalogue Number 07-1392
Description Anti-Rab40C Antibody
Alternate Names
  • RAB40C, member RAS oncogene family
  • RAR (RAS like GTPASE) like
  • RAR like
  • RAS-like GTPase
  • RAS-like, family 8, member C
  • Rar-like protein
  • Ras-like protein family member 8C
  • SOCS box-containing protein RAR3
Background Information The Rab family of proteins are a member of the Ras superfamily of small G-Proteins. At least 60 isoforms have been identified. These GTPases are primarily involved in regulating distinct steps in vesicle trafficking by regulating the dynamic assembly and disassembly of the multi-protein scaffolds that are involved in vesicle trafficking. In its active, GTP-bound state, the Rab protein recruits effector proteins to the membrane. Rabs lack intrinsic GTPase hydrolysis activity and thus rely on guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) to regulate their activity. Through these effectors, they regulate vessicle formation and movement. Rab4 and Rab11 are involved in internalization, sorting and transport to lysosomes or recycling of several membrane proteins, including GPCRs, GLUT-4, Aquaporin-2 or the H+/K+ ATPase.
References
Product Information
Format Unpurified
Presentation Rabbit Serum
Applications
Application Use Anti-Rab40C Antibody (Rabbit Polyclonal Antibody) validated in WB, IHC to detect Rab40C also known as RAS-like GTPase, SOCS box-containing protein RAR3.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application Notes Western Blot Analysis :
Immunohistochemistry Analysis:
Immunohistochemistry (IHC) staining of mouse epithelium cells during lung development. Antibody was used at a 1:1,000 dilution and stained overnight at 4°C. 10X amplification.
Biological Information
Immunogen Full-length His-tagged Rab40C recombinant protein (mouse).
Host Rabbit
Specificity Detects Rab40C
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity Note Human, Mouse, and Rat. Other species have not been tested.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • RARL
  • RASL8C
  • RAB40C
Purification Method Unpurified
UniProt Number
UniProt Summary Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Pathway: Protein modification; protein ubiquitination.
Subunit structure: Component of the probable SCF-like ECS(RAB40C) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and RAB40C. Interacts with CUL5, RNF7, TCEB1 and TCEB2.
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic sidePotential.
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.
Sequence similarities: Belongs to the small GTPase superfamily. Rab family.
Contains 1 SOCS box domain
Molecular Weight 31 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Western Blot Analysis:
This lot detected Rab40C at 1:1,000 dilution in Rat lung lysate resolved via SDS-PAGE and transferred to PVDF
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of receipt. Store at -80°C for longer term storage. Avoid repeated freeze/thaws.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

温馨提示:因厂家更改产品包装、产地或者更换随机附件等没有任何提前通知,且每位咨询者购买情况、提问时间等不同,为此以下回复仅对提问者3天内有效,其他网友仅供参考!若由此给您带来不便请多多谅解,谢谢!

我要咨询

咨询内容:
支付方式 货到付款 账期付款

服务热线

0771-3293894