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ANTI-NUMB (PAN-ISO)PC 12-301

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货号：07-207

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H IH(P), IP Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 07-2070-I
Replaces 07-2070
Description Anti-PRDM9 Antibody
Alternate Names
  • Histone-lysine N-methyltransferase PRDM9
  • PR domain zinc finger protein 9
  • PR domain-containing protein 9
Background Information Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Like other PR-domain-containing proteins, PRDM9 (also known as MEISETZ, or Meiosis-induced factor containing PR/SET domain and zinc-finger motif) is thought to be involved in transcriptional regulation. PRDM9/MEISETZ is a novel histone tri-methyltransferase that regulates meiosis-specific epigenesis. PRDM9/MEISETZ catalyses H3K4 trimethylation and activates transcription through its methylation activity. It contains a KRAB motif also found in SSX genes.
References
Product Information
Format Affinity Purified
Control
  • Human seminiferous tubules tissue
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Detect PRDM9 using this rabbit polyclonal antibody, Anti-PRDM9 Antibody validated for use in IHC (Paraffin) & IP.
Key Applications
  • Immunohistochemistry (Paraffin)
  • Immunoprecipitation
Application Notes Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected PRDM9 in human pancreas tissue.
Immunoprecipitation Analysis: A representative lot immunoprecipitated 10 µg of PRDM9 from human testis tissue lysate.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human PRDM9.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PRDM9
  • PFM6
Purification Method Affinity Purfied
UniProt Number
Molecular Weight ~103 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunohistochemistry in human seminiferous tubules tissue.

Imunnohistochemistry Analysis: A 1:200 dilution of this antibody detected PRDM9 in human seminiferous tubules tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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