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Anti-TrkC (goat polyclonal IgG)

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货号：07-226

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Gt Purified Polyclonal Antibody
Description
Catalogue Number 07-226
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-TrkC Antibody
References
Product Information
Format Purified
Applications
Application Detect TrkC using this Anti-TrkC Antibody validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Extracellular domain of rat TrkC receptor, corresponding to amino acid residues 1-429
Host Goat
Isotype IgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
Gene Symbol
  • NTRK3
  • TRKC
  • Trk-C
  • gp145(trkC)
  • GP145-TrkC
Purification Method Protein G Chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q16288 # Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
SIZE: 839 amino acids; 94428 Da
SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.
PTM: Ligand-mediated auto-phosphorylation.
SIMILARITY: SwissProt: Q16288 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 LRR (leucine-rich) repeats. & Contains 1 protein kinase domain.
Molecular Weight 145kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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