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Anti-CD4 (human), FITC, clone RPA-T4

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货号：MABF1717

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC, ICC, WB, ELISA M Purified Monoclonal Antibody
Description
Catalogue Number MABF117
Description Anti-Myeloid differentiation-2 (MD-2) Antibody, clone IIC1
Alternate Names
  • Lymphocyte antigen 96
  • Ly-96
  • ESOP-1
  • Protein MD-2
Background Information Myeloid Differentiation-2 (MD-2) is a small secreted glycoprotein that binds with cytokine-like affinities to both the hydrophobic portion of lipopolysaccharides (LPS) and the extracellular domain of Toll-like Receptor 4 (TLR4). TLR-4 is activated by its natural ligand(s), the presence of extracellular MD-2, and most lipopolysaccharides (glycan complexes which may be produced by Gram-negative bacteria). MD-2 also interacts with TLR2 in response to cell wall components of Gram-positive and Gram-negative bacteria.
References
Product Information
Format Purified
Control
  • PBMC cells.
Presentation Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Applications
Application Detect Myeloid differentiation-2 (MD-2) using this Anti-Myeloid differentiation-2 (MD-2) Antibody, clone IIC1 validated for use in FC, IC, WB, ELISA.
Key Applications
  • Flow Cytometry
  • Immunocytochemistry
  • Western Blotting
  • ELISA
Application Notes Flow Cytometry Analysis: A representative lot from an independent laboratory detected Myeloid differentiation-2 in human monocytes and HEK293 cells stably expressing Flag-tagged MD2. (Sandanger, Ø, et al. (2009). J Immunol. 182(1):588-595.)

Immunocytometry Analysis: A representative lot from an independent laboratory detected Myeloid differentiation-2 in human monocites. (Sandanger, Ø, et al. (2009). J Immunol. 182(1):588-595.)

Western Blot Analysis: A representative lot from an independent laboratory detected Myeloid differentiation-2 in CHO cell lysates expressing MD2 and Flag-tagged MD2 (Sandanger, Ø, et al. (2009). J Immunol. 182(1):588-595.)

ELISA Analysis: A representative lot from an independent laboratory detected Myeloid differentiation-2 in supernatent from unstimulated and IL-10 stimulated human monocytes. (Sandanger, Ø, et al. (2009). J Immunol. 182(1):588-595.)
Biological Information
Immunogen Mouse MD-2 and HEK293 cells stably expressing TLR4 and MD-2.
Clone IIC1
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgMκ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene Symbol
  • LY96
  • ESOP1
  • MD2
Purification Method Purified by Ion-Exchange Chromatography
UniProt Number
UniProt Summary FUNCTION: Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.

SUBUNIT STRUCTURE: Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binds to the extracellular domains of TLR2 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex.

SUBCELLULAR LOCATION: Secreted › extracellular space.
Molecular Weight 18 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Flow Cytometry in PBMC cells.

Flow Cytometry Analysis: 1 µg/mL of this antibody detected Myeloid differentiation-2 in 1X10E5 PBMC cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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