Anti-TIGIT (mouse), PE, clone 1G9 (mouse monoclonal) - 炼石商城

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Anti-TIGIT (mouse), PE, clone 1G9 (mouse monoclonal)

市场价：: 0.00

促销价：: ¥0.00

货号：MABF1419

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M	FC	M	PE	Monoclonal Antibody

Description
Catalogue Number	MABF1419
Description	Anti-TIGIT (mouse), PE, clone 1G9 Antibody
Alternate Names	T-cell immunoreceptor with Ig and ITIM domains V-set and transmembrane domain-containing protein 3 TIGIT
Background Information	The 1G9 antibody reacts with mouse TIGIT (T cell Ig and ITIM domain), a 26 kDa member of the CD28 receptor family which is reported to regulate T cell receptor (TCR) activation. Within the CD28 family of receptors there are those which have co-stimulatory activity, such as CD28 and CTLA-4, as well as more recently identified receptors like TIGIT which are proposed to provide co-inhibitory signals. TIGIT is expressed and upregulated on activated T cells, and is also expressed on memory and regulatory T cells. Upon engagement by its ligands, CD112 and CD155, TIGIT signaling inhibits T cell proliferation and suppresses T cell responses, without triggering cell deletion. A second inhibitory effect of TIGIT signaling is the generation of immunoregulatory dendritic cells, which secrete IL-10 and TGF-beta to further inhibit T cell function.The 1G9 antibody may be used for flow cytometric analysis of TIGIT, which is expressed at very high levels on T regulatory cells (Tregs) and activated conventional T cells, as well as memory T cells and NK cells.

References

Product Information
Format	PE
Presentation	Purified Mouse monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.

Applications
Application	Anti-TIGIT (mouse), PE, clone 1G9 Antibody is an antibody against TIGIT for use in Flow Cytometry.
Key Applications	Flow Cytometry

Biological Information
Immunogen	Immunogen information for this antibody is proprietary information.
Clone	1G9
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Species Reactivity	Mouse
Antibody Type	Monoclonal Antibody
Gene Symbol	Tigit
Purification Method	Purified by size-exclusion chromatography
UniProt Number	P86176

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. Flow Cytometry Analysis: 0.25 μg from a representative lot detected TIGIT in one million C57Bl/6 splenocytes.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt. Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

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