Anti-CD117 (c-Kit) (mouse), PE-Cy7, clone ACK2 (rat monoclonal) - 炼石商城

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Anti-CD117 (c-Kit) (mouse), PE-Cy7, clone ACK2 (rat monoclonal)

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促销价：: ¥0.00

货号：MABF1499

品牌：Millipore 密理博

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北京朝阳

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M	FC	R	PE-Cy7	Monoclonal Antibody

Description
Catalogue Number	MABF1499
Description	Anti-CD117 (c-Kit) (mouse), PE-Cy7, clone ACK2 Antibody
Alternate Names	Mast/stem cell growth factor receptor Kit (SCFR) Proto-oncogene c-Kit Tyrosine-protein kinase Kit CD117 CD117 (c-Kit)
Background Information	The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo. Please choose the appropriate format for each application. In addition, the antibody is reported to be cross-reactive with rat c-Kit and is extensively published for use in this species.

References

Product Information
Format	PE-Cy7
Presentation	Purified Rat monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.

Applications
Application	Anti-CD117 (c-Kit) (mouse), PE-Cy7, clone ACK2 Antibody is an antibody against CD117 for use in Flow Cytometry.
Key Applications	Flow Cytometry

Biological Information
Immunogen	Immunogen information for this antibody is proprietary information.
Clone	ACK2
Concentration	Please refer to lot specific datasheet.
Host	Rat
Species Reactivity	Mouse
Antibody Type	Monoclonal Antibody
Gene Symbol	Kit SI
Purification Method	Purified by size-exclusion chromatography
UniProt Number	P05532

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. Flow Cytometry Analysis: 0.5 μg from a representative lot detected CD117 (c-Kit) in one million C57Bl/6 bone marrow cells.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt. Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

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