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Rb X 14-3-3 sigma

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货号：AB9742

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
B, Ch, H, M, R, Sh WB Rb Serum Polyclonal Antibody
Description
Catalogue Number AB9742
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-14-3-3 σ Antibody
Background Information Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer's.

The 14-3-3 sigma antibody is one of a panel of antibodies that were generated against 14-3-3 isoforms and have demonstrated their potential for use as an ELISA-based diagnostic tool. These antibodies will allow the research to investigate the role of this protein in key cellular processes and neurological disorders such as Creutzfeldt-Jakob, Alzheimer's and Parkinson's Disease.
References
Product Information
Format Serum
Presentation Liquid.
Applications
Application Anti-14-3-3 σ Antibody is an antibody against 14-3-3 σ for use in WB.
Key Applications
  • Western Blotting
Application Notes Western blot: 1:3000

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide from the N-terminal area of sheep 14-3-3 sigma.
Host Rabbit
Specificity 14-3-3 sigma. By Western blot the antibody recognizes the ~30 kDa protein.
Species Reactivity
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Sheep
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SFN
  • YWHAS
  • HME1
  • stratifin
  • Stratifin
Purification Method Serum
UniProt Number
UniProt Summary FUNCTION: SwissProt: P31947 # p53-regulated inhibitor of G2/M progression.
SIZE: 248 amino acids; 27774 Da
SUBUNIT: Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Secreted. Note=May be secreted by a non-classical secretory pathway.
TISSUE SPECIFICITY: Present mainly in tissues enriched in stratified squamous keratinising epithelium.
SIMILARITY: SwissProt: P31947 ## Belongs to the 14-3-3 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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