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Rb X 14-3-3 gamma

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货号：AB9738

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
B, Ch, H, M, R, Sh ELISA, WB, IHC Rb Serum Polyclonal Antibody
Description
Catalogue Number AB9738
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-14-3-3 γ Antibody
Background Information Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer's.

The 14-3-3 gamma antibody is one of a panel of antibodies that were generated against 14-3-3 isoforms and have demonstrated their potential for use as an ELISA-based diagnostic tool. These antibodies will allow the research to investigate the role of this protein in key cellular processes and neurological disorders such as Creutzfeldt-Jakob, Alzheimer's and Parkinson's Disease.
References
Product Information
Format Serum
Presentation Liquid.
Applications
Application Anti-14-3-3 γ Antibody detects level of 14-3-3 γ & has been published & validated for use in ELISA, WB, IH.
Key Applications
  • ELISA
  • Western Blotting
  • Immunohistochemistry
Application Notes Western blot: 1:6,000-1:12,000 using ECL.
Immunohistochemistry: 1:400-1:800 on mouse brain tissue which was treated by hydrated autoclaving at 121°C for 15 minutes prior to immunolabeling. Endogenous peroxidase was blocked with hydrogen peroxide in methanol and non-specific labeling with normal goat serum at 1:20 for 5 minutes.
ELISA
Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide from the N-terminal area of sheep 14-3-3 gamma.
Host Rabbit
Specificity 14-3-3 gamma. By Western blot the antibody recognizes the ~30 kDa protein.
Species Reactivity
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Sheep
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.
Gene Symbol
  • YWHAG
  • KCIP-1
  • 14-3-3GAMMA
Purification Method Serum
UniProt Number
UniProt Summary FUNCTION: SwissProt: P61981 # Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
SIZE: 247 amino acids; 28303 Da
SUBUNIT: Homodimer. Interacts with RAF1 and SSH1.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Highly expressed in brain, skeletal muscle, and heart.
PTM: Phosphorylated by various PKC isozymes.
SIMILARITY: SwissProt: P61981 ## Belongs to the 14-3-3 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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