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Anti-KLK6, clone 27-4 (mouse monoclonal)

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货号：MABN874

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, ELISA, IAP M Purified Monoclonal Antibody
Description
Catalogue Number MABN874
Description Anti-KLK6 Antibody, clone 27-4
Alternate Names
  • Kallikrein-6
  • hK6
  • Neurosin
  • Protease M
  • Serine protease 18
  • Serine protease 9
  • SP59
  • Zyme
Background Information Kallikrein-6 (UniProt Q92876; also known as hK6, Neurosin, Protease M, Serine protease 18, Serine protease 9, SP59, Zyme) is encoded by the KLK6 (also known as PRSS18, PRSS9) gene (Gene ID 5653) in human. Kallikrein-6 belongs to the kallikrein subfamily of serine proteases, members of which are involved in diverse physiological functions and many are used clinically as biomarkers for cancers. Originally identified due to its aberrant expression in mammary and ovarian cancers, kallikrein-6 is expressed in a wide range of tissues, including breast, kidney, and the central nervous system. Kallikrein-6 is known to cleave components of the extracellular matrix (ECM) and is reported to be involved in multiple cellular processes, including inflammation, receptor activation, and apoptosis. In addition, deregulated KLK6 expression occurs in neurodegenerative and skin disorders, and is a common event in many types of human cancers. Consequently, KLK6 represents a promising biomarker of early diagnosis and/or unfavorable prognosis in these human malignancies. Kallikrein-6 is initially produced as a preproprotein with a signal (aa 1-16) and a propeptide (aa 17-21), cleavage of which releases the mature protein (aa 22-244).
References
Product Information
Format Purified
Presentation Purified mouse monoclonal IgG2bκ antibody in 0.1 M sodium bicarbonate buffer, pH 8.2 with 0.02% sodium azide.
Applications
Application Anti-KLK6 Antibody, clone 27-4 is an antibody against KLK6 for use in Western Blotting, ELISA, Immunoaffinity Purification.
Key Applications
  • Western Blotting
  • ELISA
  • Immunoaffinity Purification
Application Notes Western Blotting Analysis: 0.5 µg/mL from a representative lot detected kallikrein-6 in 10 µg of human brain tissue lysate.
ELISA Analysis: Representative lots were employed as the capture antibody in combination with biotin-conjugated clone E24 (Cat. No. MABN873) as the detection antibody for analyzing kallikrein-6 levels in ovarian cytosolic extracts as well as ascites fluids from ovarian cancer patients (Shan, S.J., et al. (2007). Br. J. Cancer. 96(2):362-372; Luo, L.Y., et al. (2006). Tumor Biol. 27:227-234).
Immunoaffinity Purification: A representative lot was conjugated to resins and employed for the affinity purification of kallikrein-6 from human cerebrospinal fluids (CSFs) and ascites fluids (Kuzmanov, U., et al. (2009). Mol. Cell. Proteomics. 8(4):791-798).
Biological Information
Immunogen Recombinant human kallikrein-6.
Clone 27-4
Concentration Please refer to lot specific datasheet.
Host Mouse
Specificity Clone E24 was raised against the canonical form of human kallikrein-6 recombinant protein. Reactivity against kallikrein-6 spliced isoforms 2 and 3 reported by UniProt (Q92876) has not been determined.
Isotype IgG2bκ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • KLK6
  • PRSS18
  • PRSS9
UniProt Number
Molecular Weight ~27 kDa observed. 26.86 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in human ovary tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected kallikrein-6 in 10 µg of human ovary tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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