Rb X 14-3-3 beta

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货号：AB9730

品牌：Millipore 密理博

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北京朝阳

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
B, H, M, R, Rb, Sh	ELISA, WB, IHC	Rb	Serum	Polyclonal Antibody

Description
Catalogue Number	AB9730
Replaces	04-1089
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-14-3-3 β Antibody
Background Information	Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer's. The 14-3-3 beta antibody is one of a panel of antibodies that were generated against 14-3-3 isoforms and have demonstrated their potential for use as an ELISA-based diagnostic tool. These antibodies will allow the research to investigate the role of this protein in key cellular processes and neurological disorders such as Creutzfeldt-Jakob, Alzheimer's and Parkinson's Disease.

References

Product Information
Format	Serum
Presentation	Liquid.

Applications
Application	Detect 14-3-3 β using this Anti-14-3-3 β Antibody validated for use in ELISA, WB, IH.
Key Applications	ELISA Western Blotting Immunohistochemistry
Application Notes	Western blot: 1:3,000 using ECL Immunohistochemistry: 1:300-1:600 on mouse brain tissue which was treated by hydrated autoclaving at 121°C for 15 minutes prior to immunolabeling. Endogenous peroxidase was blocked with hydrogen peroxide in methanol and non-specific labeling with normal goat serum at 1:20 for 5 minutes. ELISA Optimal working dilutions must be determined by end user.

Biological Information
Immunogen	Synthetic peptide from the N-terminal area of sheep 14-3-3 beta.
Host	Rabbit
Specificity	14-3-3 beta. By Western blot the antibody recognizes the ~30 kDa protein.
Species Reactivity	Bovine Human Mouse Rat Rabbit Sheep
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_003404.3 NM_139323.2
Entrez Gene Summary	This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.
Gene Symbol	YWHAB KCIP-1 HS1 GW128
Purification Method	Serum
UniProt Number	P31946
UniProt Summary	FUNCTION: SwissProt: P31946 # Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. SIZE: 246 amino acids; 28082 Da SUBUNIT: Homodimer. Interacts with SSH1. SUBCELLULAR LOCATION: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. PTM: Isoform alpha differs from isoform beta in being phosphorylated (By similarity). & Isoform Short contains a N-acetylmethionine at position 1 (By similarity). SIMILARITY: SwissProt: P31946 ## Belongs to the 14-3-3 family.
Molecular Weight	30 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap

Storage and Shipping Information

Storage Conditions

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap