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Rb X Cleaved PARP

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货号：AB3620

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB3620
Replaces 04-576
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-PARP Cleaved Form Antibody
Alternate Names
  • Poly [ADP-ribose] polymerase 1
  • PARP-1
  • NAD(+) ADP-ribosyltransferase 1
  • ADPRT 1
  • Poly[ADP-ribose] synthase 1
  • ARTD1
Background Information PARP, a 116 kDa poly ADP-ribose polymerase, is a conserved nuclear enzyme implicated in DNA repair and in the apoptosis response. This protein is one of the main in vivo cleavage targets of caspase-3. PARP is cleaved into two fragments: its N-terminal 24 kDa fragment, containing its DNA binding domain, and its C-terminal 89 kDa catalytic domain.
References
Product Information
Format Purified
Presentation Affinity purified immunoglobulin. Liquid in PBS, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Applications
Application Anti-PARP Cleaved Form Antibody detects level of PARP Cleaved Form & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Western blot: 0.5 – 4 µg/mL
Immunocytochemistry: 10-20 µg/mL

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity AB3620 detects only the cleaved large 89kDa subunit of human PARP and does not detect the full length PARP. The immunogen sequence is not strongly conserved between human, mouse and rat.
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Gene Symbol
  • PARP1
  • poly(ADP-ribosyl)transferase
  • PARP-1
  • PARP
  • NAD
  • pADPRT-1
  • ADPRT1
  • Poly
  • ADPRT
  • PPOL
  • EC 2.4.2.30
UniProt Number
UniProt Summary FUNCTION: SwissProt: P09874 # Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
SIZE: 1014 amino acids; 113084 Da
SUBUNIT: Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with ZNF423 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR. & Poly-ADP-ribosylated by PARP2.
SIMILARITY: SwissProt: P09874 ## Contains 1 BRCT domain. & Contains 1 PARP alpha-helical domain. & Contains 1 PARP catalytic domain. & Contains 2 PARP-type zinc fingers.
MISCELLANEOUS: The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain frozen at -20°C. For optimal storage, aliquot and freeze at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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