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Rb X Active Caspase-9

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货号：AB3629

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H IP, WB, ICC Rb Purified Polyclonal Antibody
Description
Catalogue Number AB3629
Replaces 04-443
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Caspase 9 Antibody, active (cleaved) form
Background Information Caspase-9 is an important member of the caspase family. When cytochrome c is released from the mitochondria early upon apoptosis induction, it associates with Apaf-1 and procaspase-9 and forms an apoptosome. This complex cleaves procaspase-9 into a large 37kDa subunit and a small 10kDa subunit.
References
Product Information
Format Purified
Presentation Affinity purified immunoglobulin. Liquid in PBS, containing 50% glycerol, 0.5% BSA and 0.02% thimerosal.
Applications
Application Anti-Caspase 9 Antibody, active (cleaved) form detects level of Caspase 9 & has been published & validated for use in IP, WB & IC.
Key Applications
  • Immunoprecipitation
  • Western Blotting
  • Immunocytochemistry
Application Notes Western blot: 0.5-4 μg/mL

Immunoprecipitation: 10-20 μg/mL

Immunocytochemistry: 10-20 μg/mL

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide. FQEGLRTFDQLD
Epitope active (cleaved) form
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity AB3629 detects only the cleaved large 37kDa subunit and does not detect the precursor form in cells undergoing apoptosis. It also does not detect other caspases.
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms.
Gene Symbol
  • CASP9
  • CASP-9
  • ICE-LAP6
  • APAF3
  • MCH6
  • CASPASE-9c
  • OTTHUMP00000044594
  • APAF-3
  • EC 3.4.22.62 [Contains: Caspase-9 subunit p35
  • Caspase-9 subunit p10].
UniProt Number
UniProt Summary FUNCTION: SwissProt: P55211 # Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
SIZE: 416 amino acids; 46281 Da
SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts with the inhibitors BIRC2, BIRC4, BIRC5 and BIRC7.
TISSUE SPECIFICITY: Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues.
PTM: Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase- 3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
SIMILARITY: SwissProt: P55211 ## Belongs to the peptidase C14 family. & Contains 1 CARD domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain frozen at -20°C. For optimal storage, aliquot and freeze at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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