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Rb X Vasopressin

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货号：AB1565

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Rb, Sh ICC, IH(P), RIA, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number AB1565
Replaces AB937
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Vasopressin Antibody
References
Product Information
Format Serum
Control
  • Hypothalamus
Presentation Neat rabbit antisera. Liquid, with 0.1% sodium azide.
Applications
Application Anti-Vasopressin Antibody detects level of Vasopressin & has been published & validated for use in IC, IH(P), RIA & WB.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry (Paraffin)
  • Radioimmunoassay
  • Western Blotting
Application Notes Immunohistochemistry: 1:5,000-1:10,000 (18-24 hour incubation) on formalin, Bouin's or Zamboni's fixed tissue. Will react on paraffin embedded tissue.

Immunocytochemistry: 1:1,000-1:200,000 (18-24 hour incubation) on fetal rat neurons.

Immunoblotting: 1:1,000

RIA: 1:30,000-1:750,000. Sensitivity of < 1 pg/mL.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Arginine vasopressin (Sigma) conjugated to thyroglobulin.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes Vasopressin. Less than 1% cross-reactivity with oxytocin.
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Rabbit
  • Sheep
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin II, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI).
Gene Symbol
  • AVP
  • AVP-NPII
  • VP
  • AVRP
  • ARVP
  • ADH
Purification Method Unpurified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P01185 # Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.
SIZE: 164 amino acids; 17325 Da
SUBCELLULAR LOCATION: Secreted.
DISEASE: SwissProt: P01185 # Defects in AVP are the cause of autosomal dominant neurohypophyseal diabetes insipidus (ADNDI) [MIM:125700]. ADNDI is characterized by persistent thirst, polydipsia and polyuria. The disease is transmitted in an autosomal dominant mode and appears to be largely if not completely penetrant. & Defects in AVP are the cause of autosomal recessive neurohypophyseal diabetes insipidus (ARNDI) [MIM:125700]. ARNDI is characterized by persistent thirst, polydipsia and polyuria. Most mutations are hypothesized to trigger neurodegeneration via disruption of preproAVP-NPII processing.
SIMILARITY: SwissProt: P01185 ## Belongs to the vasopressin/oxytocin family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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