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Rb X SNAP-25

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货号：AB1762

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
B WB, IHC Rb Serum Polyclonal Antibody
Description
Catalogue Number AB1762
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-SNAP-25 Antibody
Alternate Names
  • Synaptosomal-associated Protein 25
References
Product Information
Format Serum
Presentation Liquid serum containing 0.1% sodium azide.
Applications
Application This Anti-SNAP-25 Antibody is validated for use in WB, IH for the detection of SNAP-25.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application Notes Western Blot: 1:1,000-1:2,000 (using ECL). Reacts strongly with a single major band (~25kDa) on denaturing Western blots of bovine adrenal medulla and rat brain fractions. Will not detect SNAP-25 following proteolysis with botulinum neurotoxins A and E.

Immunohistochemistry. Optimal fixation and tissue processing will need to be determined by the end user.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen A synthetic peptide from the C-terminal heptadeapeptide of mouse SNAP-25 (corresponding to residues Cys + 190-206: [C]RIDEANQRATKMLGSG).
Host Rabbit
Specificity SNAP-25 (synaptosome-associated protein of 25 kDa) is a SNAP (soluble N-ethylmaleimide-sensitive fusion (NSF) attachment protein) receptor (SNARE-related protein) which is tightly associated with the plasma membrane by means of the palmitoylation of a cluster cystein residues with its structure. No cross reactivity with SNAP-23 is expected.



SNAP-25 is specifically cleaved close to the carboxyl terminal by the botulinum neurotoxins (BoNT) A and E which are known to inhibit neurotransmitter release. Similar inhibitory effects of BoNT/A and E have been recorded for non-neuronal secretory cells, such as adrenal medulla, and this lead to the identification of SNAP-25 in SNARE-like complexes precipitated from chromaffin cells.
Species Reactivity
  • Bovine
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Gene Symbol
  • SNAP25
  • SNAP
  • dJ1068F16.2
  • SNAP-25
  • FLJ23079
  • RIC-4
  • SUP
  • SEC9
  • RIC4
  • bA416N4.2
UniProt Number
UniProt Summary FUNCTION: SwissProt: P60880 # t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.
SIZE: 206 amino acids; 23315 Da
SUBUNIT: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with TRIM9, RIMS1, SNAP25BP and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Found in a complex containing SYT1, SV2B and syntaxin-1 (By similarity).
TISSUE SPECIFICITY: Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.
PTM: Palmitoylated (By similarity).
SIMILARITY: SwissProt: P60880 ## Belongs to the SNAP-25 family. & Contains 2 t-SNARE coiled-coil homology domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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