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Rb X MCT8/XPCT

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货号：AB3549P

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M ELISA, WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB3549P
Replaces AB3324P
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Monocarboxylate Transporter 8 Antibody
Alternate Names
  • MCT8
  • X-linked PEST-containing Transporter
Background Information MCT8 is an integral membrane protein that is associated with the plasma membrane. A member of the Major Facilitator Superfamily, MCT8 serves as a proton-linked monocarboxylate transporter that catalyzes the rapid transport of monocarboxylates and ketone bodies across the plasma membrane. Expression of MCT8 is greatest in liver and kidney.
References
Product Information
Format Affinity Purified
Control
  • POSITIVE CONTROL: Liver or kidney extracts
Presentation Affinitypurified immunoglobulin presented as a liquid in PBS with 0.1% BSA.
Applications
Application Anti-Monocarboxylate Transporter 8 Antibody is an antibody against Monocarboxylate Transporter 8 for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application Notes Western blot: 1-5 μg/mL using ECL.
ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide (Catalog number AG202) per well.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen A 19 amino acid peptide sequence within the cytoplasmic, C-terminus of mouse MCT8. The immunogen sequence is 94% conserved in rat and 89% in human MCT8 and shows no significant sequence homology with other MCT family members.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes mouse Monocarboxylate Transporter 8.
Species Reactivity
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SLC16A2
  • DXS128E
  • DXS128
  • MCT8
  • AHDS
  • XPCT
  • MCT7
UniProt Number
UniProt Summary FUNCTION: SwissProt: P36021 # Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity).
SIZE: 539 amino acids; 59511 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Highly expressed in liver and heart.
DISEASE: SwissProt: P36021 # Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency (MCT8 deficiency) [MIM:300523]. MCT8 deficiency consists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular hormone transport. Affected patients are males with abnormal relative concentrations of three circulating iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, and impaired gaze and hearing. Heterozygous females had a milder thyroid phenotype and no neurological defects.
SIMILARITY: SwissProt: P36021 ## Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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