Anti-Sodium, Potassium, Chloride Cotransporter 1 - 炼石商城

您好！欢迎来到炼石商城请登录注册兼职小伙伴

我的购物车

0

Qiagen 凯杰 Biosharp Omega

全部商品分类

小伙伴店铺

客服热线 0771-3293894

首页抗体Millipore 密理博>

图片仅供参考，请以实物为准

收藏

Anti-Sodium, Potassium, Chloride Cotransporter 1

市场价：: 0.00

促销价：: ¥0.00

货号：AB3560P

品牌：Millipore 密理博

配送至：

北京朝阳

支付：账期货到付款

数量：

EA (预计3-5工作日到货)

亲，想了解价格请QQ咨询客服！

工作时间

周一至周五：9:00-18:00

咨询电话

0771-3293894

在线咨询

: 客服郭恒蔡玉坤曾宪飞技术咨询

浏览了该商品的用户最终购买

RNeasy Mini Kit (50) 50次

RNeasy Mini Kit (50) 50次

3720.00

Plasmid Mini Kit I(200) 200次

Plasmid Mini Kit I(200) 200...

576.00

10ul吸头，透明，袋装，可灭菌 1000支/袋，50袋/箱

10ul吸头，透明，袋装，可灭菌...

85.80

浏览了该商品的用户还浏览了

QIAfilter Plasmid Maxi Kit (10) -10

QIAfilter Plasmid Maxi Kit (...

3000.00

QIAamp DNA Blood Midi Kit (20) 20次

QIAamp DNA Blood Midi Kit (2...

2680.00

QIAamp UCP Pathogen Mini Kit (50)

QIAamp UCP Pathogen Mini Kit...

4112.00

商品介绍
商品咨询

Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R, M, H, B	ELISA, IHC, WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	AB3560P
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-Sodium Antibody, Potassium, Chloride Cotransporter 1
Alternate Names	Basolateral Na-K-Cl symporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 solute carrier family 12 sodium/potassium/chloride transporters), member 2
Background Information	The Na+/K+/Cl- Cotransporter isoform 1 (NKCC1) is involved in the transport of sodium, potassium, and chloride ions across membranes. NKCC1 mediates sodium and chloride reabsorption and plays an important role in cell volume regulation. NKCC1 is also involved in the control of normal cell proliferation, while its overexpression results in apparent cell transformation, in a manner similar to some protooncogenes (Panet, 1999). NKCC1 is inhibited by bumetanide and is also referred to as the bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1. Inhibition of NKCC1 activity by bumetanide decreases the high-[K+]o-mediated uptake of Cl , blocks astrocyte swelling, and leads to cell shrinkage under isotonic conditions in cells such as retinal pigment epithelia, ventricular myocytes, and vascular endothelial cells (Russell, 2000; Su, 2002). NKCC1 could contribute to an overload of intracellular Na+, K+, and Cl- and cell swelling in conditions such as cerebral ischemia (Yan, 2001). NKCC1 is expressed in multiple tissues with the amount of mRNA expression varying as much as thirty-fold. It is highly expressed in neurons and astrocytes through-out the brain and has been implicated in ischemic necrotic cell death.

References

Product Information
Format	Affinity Purified
Control	Spinal cord, colon.
Presentation	Affinity purified rabbit polyclonal in buffer containing PBS with 0.1% BSA.

Applications
Application	Detect Sodium using this Anti-Sodium Antibody, Potassium, Chloride Cotransporter 1 validated for use in ELISA, IH & WB.
Key Applications	ELISA Immunohistochemistry Western Blotting
Application Notes	Immunohistochemistry: It is recommended that the antibody be tried at 2-20 µg/mL on paraformaldehyde fixed tissue. ELISA: 0.5-1.0 µg/mL of a previous lot was used with 1 µg/mL control peptide per well. Optimal working dilutions must be determined by the end user.

Biological Information
Immunogen	A 22 amino acid peptide sequence near the C-terminus of rat NKCC1. (Moore-Hoon et al. 1998; Delpire et al. 1994; Payne et al. 1995; Isering et al. 1997; Mount et al. 1998).
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Recognizes rat Sodium, Potassium, Chloride Cotransporter 1 (NKCC1, BSC2, CCC1). The immunogen shows no significant sequence homology with other CCC.
Species Reactivity	Rat Mouse Human Bovine
Species Reactivity Note	Rat. Expected to cross-react with human and mouse. The immunogen sequence is 95% conserved in mouse, 86% in human, and 82% in bovine.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_009194.3
Entrez Gene Summary	By moving chloride into epithelial cells, the Na-K-Cl cotransporter SLC12A2 aids transcellular movement of chloride across both secretory and absorptive epithelia (Payne et al., 1995 [PubMed 7629105]). See also SLC12A1 (MIM 600839) and SLC12A3 (MIM 600968).[supplied by OMIM]
Gene Symbol	SLC12A2 BSC2 NKCC1 MGC104233 BSC
Purification Method	ImmunoAffinity Purified
UniProt Number	P55012
UniProt Summary	FUNCTION: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. SIZE: 1,205 amino acids; 130,950 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in many tissues. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the SLC12A transporter family.
Molecular Weight	170 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot on Rat Spinal Cord lysates. Western Blot Analysis: 1:500 dilution detected NA+K+CL- COTRANS 1 on 10 µg of Rat Spinal Cord lysates.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 6 months at -20°C in undiluted aliquots from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	50 µg

Transport Information

Supplemental Information

Specifications

登录 / 注册

购物指南免费注册批量采购购物流程购物保障

配送方式上门自提第三方配送炼石配送

支付方式货到付款账期付款

售后服务售后政策退款说明售后流程免责条款

服务热线

0771-3293894