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Ch X Leptin, Rat/Mouse

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货号：AB3521

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, R ELISA, WB Ch Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB3521
Replaces MAB3870
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Leptin Antibody
References
Product Information
Format Affinity Purified
Presentation Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Applications
Application Detect Leptin using this Anti-Leptin Antibody validated for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application Notes Immunoblotting: 1:1,000-1:5,000

ELISA: 1:1,000-1:5,000

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Recombinant rat leptin.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Chicken
Specificity Leptin, rat and mouse.
Species Reactivity
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
Gene Symbol
  • LEP
  • leptin
  • OB
  • obesity
  • OBS
UniProt Number
UniProt Summary FUNCTION: SwissProt: P41159 # May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
SIZE: 167 amino acids; 18641 Da
SUBUNIT: Interacts with SIGLEC6.
SUBCELLULAR LOCATION: Secreted.
DISEASE:SwissProt: P41159 # Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].
SIMILARITY: SwissProt: P41159 ## Belongs to the leptin family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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