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Rb X NCX1

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货号：AB3516P

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R ELISA, WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB3516P
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Sodium-Calcium Exchanger 1 Antibody
Alternate Names
  • NCX1
References
Product Information
Format Affinity Purified
Presentation Affinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA.
Applications
Application Anti-Sodium-Calcium Exchanger 1 Antibody is an antibody against Sodium-Calcium Exchanger 1 for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application Notes Western blot: 1-10 μg/mL using ECL.





ELISA: 0.5-1 μg/mL using 1 μg/mL control peptide per well.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen A 23 amino acid peptide sequence within the cytoplasmic domain 3 rat NCX1 (Low et al. 1993; Furman et al. 1993; Lee et al. 1994; Nicoll et al. 1996; Kumoro et al. 1992; Blaustein & Lederer 1999).
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes rat Sodium Calcium Exchanger 1 (NCX1). The immunogen shows no significant sequence homology with other NCX proteins.
Species Reactivity
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM]
Gene Symbol
  • SLC8A1
  • NCX1
  • DKFZp779F0871
  • +Ca
  • CNC
  • Na
  • MGC119581
UniProt Number
UniProt Summary FUNCTION: SwissProt: P32418 # Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
SIZE: 973 amino acids; 108547 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Cardiac sarcolemma.
SIMILARITY: SwissProt: P32418 ## Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. & Contains 2 Calx-beta domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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