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Rb X Muscarinic Acetylchol Rcpt M2

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货号：AB9452

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H IH(P) Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB9452
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Muscarinic Acetylcholine Receptor M2 Antibody
References
Product Information
Format Affinity Purified
Presentation Affinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
Applications
Application Detect Muscarinic Acetylcholine Receptor M2 using this Anti-Muscarinic Acetylcholine Receptor M2 Antibody validated for use in IH(P).
Key Applications
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Synthetic peptide from the 3rd cytoplasmic domain of human Muscarinic Acetylcholine Receptor M2.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes Muscarinic Acetylcholine Receptor M2.
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.
Gene Symbol
  • CHRM2
  • MGC120006
  • FLJ43243
  • MGC120007
  • HM2
UniProt Number
UniProt Summary FUNCTION: SwissProt: P08172 # The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
SIZE: 466 amino acids; 51715 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P08172 ## Belongs to the G-protein coupled receptor 1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Availability by Geography
  • This product is not available for sale in Japan.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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