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Anti-Integrin a4 Antibody, clone PS/2

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货号：CBL1304

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M FC, IF, IP, IHC, FUNC R Purified Monoclonal Antibody
Description
Catalogue Number CBL1304
Replaces 04-1131
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Integrin α4 Antibody, clone PS/2
Alternate Names
  • CD49d
  • VLA-4
Background Information Virtually all lymphoid and myeloid cells in bone marrow are reactive with the anti-VLA-4 antibody. VLA-4 is absent or minimally detectable on stromal cells. Myeloid cells maintained in Dexter-type long-term cultures of murine bone marrow are positive, as are lymphoid cells from Whitlock-White cultures.
References
Product Information
Format Purified
Presentation Purified rat IgG2bκ in 0.01 M phosphate buffer, pH 7.1 containing no preservatives.
Applications
Application Anti-Integrin α4 Antibody, clone PS/2 detects level of Integrin α4 & has been published & validated for use in FC, IF, IP, IH.
Key Applications
  • Flow Cytometry
  • Immunofluorescence
  • Immunoprecipitation
  • Immunohistochemistry
  • Affects Function
Application Notes Flow cytometry: 2 μg per 106 cells

Immunohistochemistry on frozen tissue sections

Immunoprecipitation

Cell adhesion assays

Optimal working dilutions must be determined by the end user.
Biological Information
Clone PS/2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rat
Specificity Clone PS/2 recognises the murine alpha4 chain of the VLA-4 integrin heterodimer, 150 kDa. The antibody also reacts with human VLA-4.
Isotype IgG2bκ
Species Reactivity
  • Human
  • Mouse
Species Reactivity Note Human, Mouse. Reactivity with other species has not been confirmed.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
Gene Symbol
  • ITGA4
  • IA4
  • MGC90518
  • VLA-4
  • CD49D
  • CD49d
UniProt Number
UniProt Summary FUNCTION: SwissProt: P13612 # Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
SIZE: 1038 amino acids; 115333 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: SwissProt: P13612 The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
PTM: Phosphorylation on Ser-1027 inhibits PXN binding.
SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20ºC for up to 12 months from date of receipt.Upon first use, aliquot into smaller quantities to avoid additional freeze/thaw cycles.
Packaging Information
Material Size 500 µg
Transport Information
Supplemental Information
Specifications

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