Rb X KCC2b

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货号：AB3264

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R	ELISA, WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	AB3264
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-K+/Cl- Cotransporter 2b Antibody, pain, NT
Alternate Names	KCC2 Solute Carrier Family 12 Member 5

References

Product Information
Format	Affinity Purified
Presentation	Affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.4, containing 0.1% BSA and 0.1% sodium azide.

Applications
Application	Anti-K+/Cl-Cotransporter 2b Antibody, pain, N-terminus is an antibody against K+/Cl-Cotransporter 2b for use in ELISA & WB.
Key Applications	ELISA Western Blotting
Application Notes	Western blot: 1-10 μg/mL using ECL.Approximate size on reduced westerns is 140-145kDa; membrane preparations and proteinase inhibitors are strongly recommended. See protocol under Technical Service at www.chemicon.com. ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well. Optimal working dilutions must be determined by the end user.

Biological Information
Immunogen	An 18 amino acid peptide within the cytoplasmic, N-terminus of rat KCC2b.
Epitope	N-terminus
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Recognizes K+ Cl- Cotransporter-2 (KCC2b). The immunogen shows no significant sequence homology with other KCCs or CCC. AB3264 is specific for KCC2b and will not detect KCC2a. SPECIES REACTIVITIES: The immunogen sequence is 100% conserved in mouse. Reactivity with other species has not been confirmed.
Species Reactivity	Rat
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_020708.3
Entrez Gene Summary	K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons.
Gene Symbol	SLC12A5 KIAA1176 KCC2 hKCC2
UniProt Number	Q9H2X9
UniProt Summary	FUNCTION: SwissProt: Q9H2X9 # Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons. SIZE: 1139 amino acids; 126184 Da SUBUNIT: Homomultimer and heteromultimer with other K-Cl cotransporters (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Brain specific. Detected in neuronal cells. SIMILARITY: SwissProt: Q9H2X9 ## Belongs to the SLC12A transporter family. MISCELLANEOUS: Inhibited by furosemide and bumetanide.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial on a tabletop centrifuge to dislodge any liquid in the container's cap.

Storage and Shipping Information

Storage Conditions

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial on a tabletop centrifuge to dislodge any liquid in the container's cap.