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Rb X PARP

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货号：AB16661

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
B, H, M, R ELISA, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number AB16661
Replaces 04-575; 04-576
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-PARP Poly ADP-ribose Polymerase-1 Antibody
Alternate Names
  • Poly [ADP-ribose] polymerase 1
  • PARP-1
  • NAD(+) ADP-ribosyltransferase 1
  • ADPRT 1
  • Poly[ADP-ribose] synthase 1
  • ARTD1
References
Product Information
Format Serum
Presentation Antiserum containing 0.05% sodium azide. Liquid containing 0.05% sodium azide.
Applications
Application This Anti-PARP Poly ADP-ribose Polymerase-1 Antibody is validated for use in ELISA, WB for the detection of PARP Poly ADP-ribose Polymerase-1.
Key Applications
  • ELISA
  • Western Blotting
Application Notes Western blot: 1:500 using alkaline phosphatase.

ELISA

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide based on the sequence from the C-terminal portion of the bovine PARP automodification domain (amino acids 509-524) conjugated to a carrier.
Host Rabbit
Specificity Recognizes 116 kDa PARP-1 and the 85 kDa apoptosis-related cleavage fragment.
Species Reactivity
  • Bovine
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Gene Symbol
  • PARP1
  • poly(ADP-ribosyl)transferase
  • pADPRT-1
  • PARP-1
  • ADPRT1
  • Poly
  • PARP
  • ADPRT
  • PPOL
  • NAD
  • EC 2.4.2.30
UniProt Number
UniProt Summary FUNCTION: SwissProt: P09874 # Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
SIZE: 1014 amino acids; 113084 Da
SUBUNIT: Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with ZNF423 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR. & Poly-ADP-ribosylated by PARP2.
SIMILARITY: SwissProt: P09874 ## Contains 1 BRCT domain. & Contains 1 PARP alpha-helical domain. & Contains 1 PARP catalytic domain. & Contains 2 PARP-type zinc fingers.
MISCELLANEOUS: The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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