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Rb X Ms Leptin

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货号：AB1673

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M RIA, WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB1673
Replaces AB3385P
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Leptin Antibody
References
Product Information
Format Purified
Presentation Purified immunoglobulin in PBS. Contains no preservative.
Applications
Application Anti-Leptin Antibody detects level of Leptin & has been published & validated for use in RIA & WB.
Key Applications
  • Radioimmunoassay
  • Western Blotting
Application Notes Western blot: 1:1,000

RIA: 1:1,000

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Recombinant mouse leptin.
Host Rabbit
Specificity Reacts with mouse leptin.
Species Reactivity
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.[supplied by OMIM]
Gene Symbol
  • LEPR
  • DB
  • OBR
  • CD295
  • OB-R
  • LEP-R
  • HuB219
UniProt Number
UniProt Summary FUNCTION: SwissProt: P48357 # Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).
SIZE: 1165 amino acids; 132494 Da
SUBUNIT: On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3 (By similarity). Interaction with SOCS3 inhibits LRb signaling (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform E: Secreted (Probable).
TISSUE SPECIFICITY: Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
DOMAIN: SwissProt: P48357 The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs. & The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding. & The box 1 motif is required for JAK interaction and/or activation.
PTM: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 (By similarity). Phosphorylation on Tyr-1141 is required for STAT3 binding/activation.
SIMILARITY: Belongs to the type I cytokine receptor family. Type 2 subfamily. & Contains 4 fibronectin type-III domains. & Contains 1 Ig-like (immunoglobulin-like) domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in diluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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