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Rb X Phospho-CaMKII (Thr305)

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货号：AB3865

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Dr, H, M, R WB Rb Serum Polyclonal Antibody
Description
Catalogue Number AB3865
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-CaMKII Antibody, phospho-specific (Thr305)
References
Product Information
Format Serum
Presentation Neat serum.
Applications
Application Detect CaMKII using this Anti-CaMKII Antibody, phospho-specific (Thr305) validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Western blot: 1:1000

Dot blots: 1:1000

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated Thr305 of CaMKII. Sequence is identical in human, mouse, rat, bovine, chicken, Drosophila, and Limulus and in alpha, beta, and delta isoforms.
Epitope phospho-specific (Thr305)
Host Rabbit
Specificity Recognizes the alpha, beta and gamma isoforms of CaMKII (Ca2+/calmodulin-dependent protein kinase II) when phosphorylated at Thr305. CaMKII is a prominent serine/threonine kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.
Species Reactivity
  • Drosophila
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
Gene Symbol
  • CAMK2A
  • KIAA0968
  • CAMKA
  • EC 2.7.11.17
Modifications
  • Phosphorylation
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9UQM7 # CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
SIZE: 478 amino acids; 54030 Da
SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1 and SYNGAP1 (By similarity).
SUBCELLULAR LOCATION: Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity).
SIMILARITY: SwissProt: Q9UQM7 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20ºC for up to one year from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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