Rabbit Anti-Acetyl Lysine Polyclonal Antibody

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Rabbit Anti-Acetyl Lysine Polyclonal Antibody

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货号：AB3879

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
A	ELISA, IF, IHC, IP, WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	AB3879
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-Acetyl Lysine Antibody
Background Information	In the nucleus, DNA is tightly packed into nucleosomes generating an environment which is highly repressive towards DNA processes such as transcription. Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression. The acetylation of non-histone proteins such as transcription factors, as well as histones appears to be involved in this process. Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains. The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain. Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation.

References

Product Information
Format	Affinity Purified
Control	TSA-treated HeLa and NIH/3T3 cells, osteosarcoma tissue.
Presentation	Purified rabbit polyclonal in buffer containing PBS with 50% glycerol.

Applications
Application	Anti-Acetyl Lysine Antibody is a high quality Rabbit Polyclonal Antibody for the detection of Acetyl Lysine & has been validated in ELISA, IF, IHC, IP & WB.
Key Applications	ELISA Immunofluorescence Immunohistochemistry Immunoprecipitation Western Blotting
Application Notes	Immunoprecipitation: A previous lot was used at 10 µg/mg crude protein. ELISA: 0.25-1 μg/mL of a previous lot was used. Immunohistochemistry: 2.5 μg/mL of a previous lot was used. Immunofluorescence: 5 μg/mL of a previous lot was used. Optimal working dilutions must be determined by end user.

Biological Information
Immunogen	Acetylated KLH.
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Recognizes proteins acetylated on lysine residues. This antibody recognizes multiple acetylated proteins including acetylated histones, acetylated BSA, and acetylated MBP, and exhibits no reaction with non-acetylated proteins.
Species Reactivity	All
Antibody Type	Polyclonal Antibody
Modifications	Acetylation
Purification Method	ImmunoAffinity Purified

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by Western Blot on Hela Acid Extract/Sodium Butyrate lysates. Western Blot Analysis: 1:500 dilution of this lot detected lysine acylated proteins on 10 μg of Hela Acid Extract/Sodium Butyrate lysates.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C in undiluted aliquots from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Storage and Shipping Information

Storage Conditions

Stable for 1 year at -20°C in undiluted aliquots from date of receipt.

Handling Recommendations:
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.