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Rb X Trace Amine Receptor 1

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货号：AB9303

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Mk, R IH(P), WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB9303
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Trace Amine Receptor 1 Antibody
Alternate Names
  • TA1
  • TAAR1
References
Product Information
Format Affinity Purified
Presentation Affinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
Applications
Application Anti-Trace Amine Receptor 1 Antibody detects level of Trace Amine Receptor 1 & has been published & validated for use in IH(P) & WB.
Key Applications
  • Immunohistochemistry (Paraffin)
  • Western Blotting
Application Notes Immunohistochemistry on paraffin embedded tissue sections.

Western blot.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Synthetic peptide from the 3rd cytoplasmic domain of human Trace Amine Receptor 1.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes Trace Amine Receptor 1 [TAAR1, TA1].
Species Reactivity
  • Human
  • Monkey
  • Rat
Species Reactivity Note The immunogen has 63% similarity with mouse.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary TAAR1 is a G protein-coupled receptor activated by trace amines. Trace amines are endogenous amine compounds that account for less than 1% of the biogenic amines in most brain regions (Bunzow et al., 2001 [PubMed 11723224]).[supplied by OMIM]
Gene Symbol
  • TAAR1
  • TA1
  • TRAR1
  • TaR-1
  • MGC138399
  • RP11-295F4.9
  • MGC126874
  • TAR1
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q96RJ0 # Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
SIZE: 339 amino acids; 39092 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestin. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle, and spleen.
SIMILARITY: SwissProt: Q96RJ0 ## Belongs to the G-protein coupled receptor 1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Availability by Geography
  • This product is not available for sale in Japan.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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