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Rb X Chk Tenascin

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货号：AB19013

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Ch IHC, IH(P), FUNC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB19013
Replaces AB1951
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Tenascin Antibody
References
Product Information
Format Affinity Purified
Control
  • Embryonic chicken brain
Presentation Affinity Purified using immobilized chicken tenascin. Provided as a liquid in PBS, containing no preservatives.
Applications
Application Anti-Tenascin Antibody is an antibody against Tenascin for use in IH, IH(P).
Key Applications
  • Immunohistochemistry
  • Immunohistochemistry (Paraffin)
  • Affects Function
Application Notes Function blocking

Western blot: Antibody recognizes a 220-240kDa band in reduced westerns; antibody reacts best with chicken, followed by human (100X less reactive). Mouse reactivity under reduced conditions is poor.

Immunohistochemistry: frozen and paraffin embedded tissues; citrate treatment useful for paraffin tissues.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Purified tenascin from embryonic chicken brain.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Reactive with tenascin from chicken and human by immunohistochemistry. Under reducing conditions, reactivity to chicken is approximately 100X greater than reactivity with human tenascin. Reactivity with mouse tenascin under reducing conditions is poor, but reacts with mouse in paraffin embedded sections.
Species Reactivity
  • Human
  • Chicken
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • TNC
  • Hexabrachion
  • HXB
  • GMEM
  • TN
  • Neuronectin
  • Tenascin-C
  • MGC167029
  • JI
  • TN-C
  • Cytotactin
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P24821 # Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
SIZE: 2201 amino acids; 240866 Da
SUBUNIT: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
PTM: N-glycosylated (By similarity).
SIMILARITY: SwissProt: P24821 ## Belongs to the tenascin family. & Contains 15 EGF-like domains. & Contains 1 fibrinogen C-terminal domain. & Contains 15 fibronectin type-III domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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