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Rb X Iron Regulatory Protein 1

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货号：AB15506

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R ELISA, WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB15506
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Iron Pegulatory Protein 1 Antibody
Alternate Names
  • IRP-1
Background Information Iron regulatory proteins (IRP-1 and IRP-2) are cytoplasmic mRNA-binding proteins that control intracellular iron levels by regulating the translation of ferritin, Tfrs, and other proteins congaing iron-responsive element (IRE) located at the 5'-UTR. IRP binds to IREs with high affinity in situation of iron starvation. Binding of IRP to IRE of ferritin represses its transcription. However, when cells are iron replete, IRPs lose their capacity to bind IREs, allowing efficient translation of ferritin and reducing Tfr mRNA half-life. Although IRP1 and IRP-2 share significant protein sequence homology, they differ in tissue distribution and mode of regulation. IRP-2/IRE-BP2 (rat/human 963 aa) is relatively less abundant than IRP-1 and lacks aconitase activity. It has a unique 73-aa insertion in the N-terminus. In the presence of high iron levels, IRP-2 is rapidly targeted to proteasome-mediated degradation. Although, both IRPs bind the consensus IREs, it is also shown that IRP-2 can recognize an exclusive IRE subset.
References
Product Information
Format Purified
Presentation Liquid in PBS with 0.1% BSA.
Applications
Application Anti-Iron Pegulatory Protein 1 Antibody detects level of Iron Pegulatory Protein 1 & has been published & validated for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application Notes Western blot: 1-10 µg/mL using ECL.
Immunohistochemistry: Not tested. Recommended testing antibody dilution:2-20 µg/mL
ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well.
Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide near the N-terminus of rat IRP-1.
Host Rabbit
Specificity Iron regulatory protein 1 (IRP-1). The immunogen sequence has no significant homology with IRP-2.
Species Reactivity
  • Rat
Species Reactivity Note Other species have not yet been tested. The immunogen sequence is 94% conserved in mouse, and 89% in human and rabbit IRP-1.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Gene Symbol
  • ACO1
  • Aconitase
  • IREBP
  • IRP1
  • OTTHUMP00000045233
  • IREB1
  • EC 4.2.1.3
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P21399 # This protein also expresses aconitase activity.
COFACTOR: Binds 1 4Fe-4S cluster per subunit (By similarity).
SIZE: 889 amino acids; 98399 Da
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: SwissProt: P21399 ## Belongs to the aconitase/IPM isomerase family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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