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Rb X Hu Cytochrome P450 CYP1A1

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货号：AB1258

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H IHC, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number AB1258
Replaces MAB3522
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Cytochrome P450 Enzyme CYP1A1 Antibody
References
Product Information
Format Serum
Presentation Rabbit antiserum. Liquid, no preservatives.
Applications
Application Anti-Cytochrome P450 Enzyme CYP1A1 Antibody detects level of Cytochrome P450 Enzyme CYP1A1 & has been published & validated for use in IH & WB.
Key Applications
  • Immunohistochemistry
  • Western Blotting
Application Notes Western blot

Immunohistochemistry

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide
Host Rabbit
Specificity Reacts with human cytochrome P450 CYP1A1 in human placental microsomal fraction and to recombinant human CYP1A1.
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
Gene Symbol
  • CYP1A1
  • CP11
  • P1-450
  • CYPIA1
  • P450-C
  • CYP1
  • P450DX
  • P450-P1
  • AHRR
  • AHH
UniProt Number
UniProt Summary FUNCTION: SwissProt: P04798 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
SIZE: 512 amino acids; 58165 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Lung, lymphocytes and placenta.
SIMILARITY: SwissProt: P04798 ## Belongs to the cytochrome P450 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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