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Human Integrin aVb5

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货号：CC1022

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number CC1022
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Human Integrin αVβ5, Octyl-β-D-glucopyranoside Formulation
Overview Integrin alphaVbeta5 was purified from human placenta by affinity chromatography using immobilized monoclonal antibodies to alphaVbeta5 integrin.
References
Product Information
Presentation Purified protein inTris buffered saline with 100mM Octyl-β-D-glucopyranoside and sodium azide
Applications
Key Applications
  • Positive Control
Application Notes Electrophoresis

Immunoblotting

Ligand binding studies. This format of alphaVbeta5 is appropriate for functional evaluation.

Optimal working dilutions must be determined by end user.
Biological Information
Concentration 433 μg/mL
Purity >95% by SDS-PAGE (silver stain)
Entrez Gene Number
Entrez Gene Summary ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
Gene Symbol
  • ITGAV
  • DKFZp686A08142
  • MSK8
  • CD51
  • VNRA
UniProt Number
UniProt Summary FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1048 amino acids; 116038 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -70°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/ thaw cycles.
Packaging Information
Material Size 25 µg
Transport Information
Supplemental Information
Specifications

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