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Ms X Troponin I

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号:MAB1691

牌:Millipore 密理博

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Replacement Information

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
B, Ch, H, M, Rb, F, Fg ELISA, WB M Purified Monoclonal Antibody
Description
Catalogue Number MAB1691
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Troponin I Antibody, a.a. 186-192, clone C5
References
Product Information
Format Purified
Control
  • POSITIVE CONTROL: heart or skeletal muscle.
Presentation Purified immunoglobulin from Protein A Sepharose. Liquid in PBS pH 7.4 with 0.1% sodium azide as a preservative.
Applications
Application Detect Troponin I using this Anti-Troponin I Antibody, clone C5 validated for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application Notes Immunohistochemistry. The antibody is not recommended for use on parafin sections.

Troponin sandwich ELISA (for labeling) with MAB3438.

Western blotting. Recognizes a band at approxinmately 22.5 kDa corresponding to troponin I.

Troponin I purification

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Bovine cardiac Troponin I.
Epitope a.a. 186-192
Clone C5
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Troponin I. Reacts with Troponin I from heart and skeletal muscle.
Isotype IgG2b
Species Reactivity
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rabbit
  • Fish
  • Frog
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Troponin I (TnI) is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle; see also TNNI1 (MIM 191042). The others are troponin T (TnT; see MIM 191041) and troponin C (TnC; see MIM 191040).[supplied by OMIM]
Gene Symbol
  • TNNI3
  • TNNC1
  • CMH7
  • MGC116817
  • cTnI
UniProt Number
UniProt Summary FUNCTION: SwissProt: P19429 # Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
SIZE: 210 amino acids; 24008 Da
SUBUNIT: Binds to actin and tropomyosin. Interacts with TRIM63.
DISEASE: SwissProt: P19429 # Defects in TNNI3 are the cause of familial hypertrophic cardiomyopathy type 7 (CMH7) [MIM:191044]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy [MIM:192600] is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. FHC is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with a high risk of cardiac failure and sudden cardiac death. & Defects in TNNI3 are the cause of familial restrictive cardiomyopathy (RCM) [MIM:115210]. RCM is an heart muscle disorder characterized by impaired filling of the ventricles with reduced volume in the presence of normal or near normal wall thickness and systolic function. The disease may be associated with systemic disease but is most often idiopathic.
SIMILARITY: SwissProt: P19429 ## Belongs to the troponin I family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at +2-8°C for up to 6 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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