Anti-Human Interleukin-6 clone B-E8 (mouse monoclonal) - 炼石商城

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Anti-Human Interleukin-6 clone B-E8 (mouse monoclonal)

市场价：: 0.00

促销价：: ¥0.00

货号：CBL2117

品牌：Millipore 密理博

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北京朝阳

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	ELISA, FC, IHC, NEUT	M	Purified	Monoclonal Antibody

Description
Catalogue Number	CBL2117
Replaces	04-1095
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-Interleukin-6 Antibody, clone B-E8
Alternate Names	IL-6 B-cell stimulatory factor 2 Interferon beta-2

References

Product Information
Format	Purified
Presentation	The monoclonal is purified from tissue culture supernatant by ion exchange chromatography and is presented as a liquid in phosphate buffered saline, pH 7.2.

Applications
Application	Detect Interleukin-6 using this Anti-Interleukin-6 Antibody, clone B-E8 validated for use in ELISA, FC, IH, NEUT.
Key Applications	ELISA Flow Cytometry Immunohistochemistry Neutralizing
Application Notes	Blocks Interleukin-6 induced proliferation on B9 cells: 20pg of antibody neutralizes the activity of 1U of IL-6. It is recommended that the sodium azide is removed from the antibody prior to use in this application. Immunohistochemistry on frozen sections Optimal working dilutions must be determined by the end user.

Biological Information
Immunogen	Recombinant human IL-6.
Clone	B-E8
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	Recognizes natural and recombinant forms of human Interleukin-6 with an affinity of 0.5 nM. Inhibits IL-6 binding to its receptors and blocks Interleukin-6 induced proliferation on B9 cells.
Isotype	IgG1
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_000600.2
Gene Symbol	IL6 HSF BSF-2 HGF IL-6 BSF2 CDF IFNB2
Non-Reactive Species	Mouse
UniProt Number	P05231
UniProt Summary	FUNCTION: SwissProt: P05231 # IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants. SIZE: 212 amino acids; 23718 Da SUBCELLULAR LOCATION: Secreted. PTM: N- and O-glycosylated. DISEASE: SwissProt: P05231 # Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement. & At least 1 polymorphism in the IL6 gene renders HIV- infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS. SIMILARITY: SwissProt: P05231 ## Belongs to the IL-6 superfamily.

Physicochemical Information

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Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Store at 2-8°C for up to 12 months from date of receipt. For long term storage aliquot antibody into small volumes and store at -20°C. Avoid repeated freeze-thaw cycles.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

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